Naturally Occurring Swine Influenza A Virus PB1-F2 Phenotypes That Contribute to Superinfection with Gram-Positive Respiratory Pathogens
Identifieur interne : 000A38 ( Main/Exploration ); précédent : 000A37; suivant : 000A39Naturally Occurring Swine Influenza A Virus PB1-F2 Phenotypes That Contribute to Superinfection with Gram-Positive Respiratory Pathogens
Auteurs : Jenni N. Weeks-Gorospe [États-Unis] ; Heather R. Hurtig [États-Unis] ; Amy R. Iverson [États-Unis] ; Margaret J. Schuneman [États-Unis] ; Richard J. Webby [États-Unis] ; Jonathan A. Mccullers [États-Unis] ; Victor C. Huber [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2012.
Abstract
A combination of viral, bacterial, and host factors contributes to the severity and overall mortality associated with influenza virus-bacterium superinfections. To date, the virulence associated with the recently identified influenza virus protein PB1-F2 has been largely defined using models of primary influenza virus infection, with only limited assessment in models of
Url:
DOI: 10.1128/JVI.00369-12
PubMed: 22674997
PubMed Central: 3416121
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>A combination of viral, bacterial, and host factors contributes to the severity and overall mortality associated with influenza virus-bacterium superinfections. To date, the virulence associated with the recently identified influenza virus protein PB1-F2 has been largely defined using models of primary influenza virus infection, with only limited assessment in models of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
superinfection. Specifically, these studies have incorporated isogenic viruses that differ in the PB1-F2 expressed, but there is still knowledge to be gained from evaluation of natural variants derived from a nonhuman host species (swine). Using this rationale, we developed the hypothesis that naturally occurring viruses expressing variants of genes, like the PB1-F2 gene, can be associated with the severity of secondary bacterial infections. To test this hypothesis, we selected viruses expressing variants in PB1-F2 and evaluated outcomes from superinfection with three distinct Gram-positive respiratory pathogens: <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>
, <named-content content-type="genus-species">Staphylococcus aureus</named-content>
, and <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
. Our results demonstrate that the amino acid residues 62L, 66S, 75R, 79R, and 82L, previously proposed as molecular signatures of PB1-F2 virulence for influenza viruses in the setting of bacterial superinfection, are broadly associated with enhanced pathogenicity in swine in a bacterium-specific manner. Furthermore, truncated PB1-F2 proteins can preferentially increase mortality when associated with <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
superinfection. These findings support efforts to increase influenza virus surveillance to consider viral genotypes that could be used to predict increased severity of superinfections with specific Gram-positive respiratory pathogens.</p>
</div>
</front>
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<name sortKey="Huber, Victor C" sort="Huber, Victor C" uniqKey="Huber V" first="Victor C." last="Huber">Victor C. Huber</name>
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